Can confirm from personal experience, KDE Plasma is arguably the best choice.

I used it on a tiny Surface Go without issue, and I use it with a touch pen display.

You can easily rearrange the UI so things are positioned where your hands are.

Also, it’s the only setup I found where I could rely on virtual keyboards alone, after installing OnBoard.

I also tried Gnome and PopOS, and Plasma came out on top.